The NSF Quantum Leap Challenge Institute for Quantum Sensing for Biophysics and Bioengineering (NSF QuBBE)

NSF QuBBE seeks to create quantum measurements and imaging systems that exceed classical limits to extract novel information from biology.


 

Quantum Sensing for Biology

The tools for exceeding the classical limits and accessing new information are the same: quantum coherence and correlations. Coherent quantum systems enable interferometric measurements at the nanoscale, while quantum correlations permit exquisite control over multiple interactions by changing the probabilities.

Correlative Imaging

Up to this point, we have imposed a sort of hierarchy looking at organisms, tissue, cells, and molecules, and we have probed subsystems within this hierarchy…but again and again, we are surprised when these subsystems couple in important, unforeseen ways. Correlative probes using quantum light and electrons provide a new paradigm where these observations of coupling and correlation are natural and easily observed because biology is not constrained by the particular hierarchy that we must impose to break the system down into chemical or biological subunits.

 

Creating Tomorrow's Quantum Workforce

Biology and quantum science are convergent fields. NSF QuBBE will dramatically accelerate this convergence by driving use-inspired development of quantum sensing modalities and novel correlative imaging approaches. Fundamental basics science in both biology and quantum will work in tandem to create transferrable technology platforms for novel biological measurements. NSF QuBBE will further develop the next generation of scientists and workers familiar with this technology, inspire young students to pursue STEM education, and foster an understanding of quantum science in the next generation.

Welcome   5/30/2023

Kamran Mobarhan

Welcome to Dr. Kamran Mobarhan, who is joining QuBBE as the Director of Business Management and Strategic Initiatives for the NSF QuBBE Quantum Leap Challenge Institute.

In the news...   5/18/2023

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Work from the Mazziotti group looking at quantum dynamics in biology featured on CBS news.

QuBBE Summer Researcher Launches   5/4/2023

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Congratulations to QuBBE summer researcher Mya Nash on launching her graduate career at UChicago.

CZI BioHub Chicago   3/2/2023

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The Chan-Zuckerberg Initiative is launching a new $275M BioHub in Chicago to address immunity and inflammation with quantum sensing as a key technological pillar.

area.title activities within The NSF QuBBE Quantum Leap Challenge Institute at The University of Chicago

Workforce Development

area.title activities within The NSF QuBBE Quantum Leap Challenge Institute at The University of Chicago

Outreach

area.title activities within The NSF QuBBE Quantum Leap Challenge Institute at The University of Chicago

New Materials

area.title activities within The NSF QuBBE Quantum Leap Challenge Institute at The University of Chicago

Targeting Biological Processes

area.title activities within The NSF QuBBE Quantum Leap Challenge Institute at The University of Chicago

Imaging and Sensing

area.title activities within The NSF QuBBE Quantum Leap Challenge Institute at The University of Chicago

Translation

area.title activities within The NSF QuBBE Quantum Leap Challenge Institute at The University of Chicago

Quantum Academy

C. Scheibner, H. Ori, A.E. Cohen, and V. Vitelli, "", Proceedings of the National Academy of Sciences 121 e2307996120 (2024)

E.J. Mulder, B. Moser, J. Delgado, R.C. Steinhardt, and A.P. Esser-Kahn, "Evidence of Collective Influence in Innate Sensing Using Fluidic Force Microscopy", Front Immunol 15 1340384 (2024)

E.J. Mulder, B. Moser, J. Delgado, R. Steinhardt, and A.P. Esser-Kahn, "Protocol for Localized Macrophage Stimulation with Small-Molecule Tlr Agonist Via Fluidic Force Microscopy", STAR Protoc 5 102873 (2024)

C.A.Z. Bassetto, Jr., J. Pfeffermann, R. Yadav, S. Strassgschwandtner, T. Glasnov, F. Bezanilla, and P. Pohl, "Photolipid Excitation Triggers Depolarizing Optocapacitive Currents and Action Potentials", Nat Commun 15 1139 (2024)

S. Sohoni, L.T. Lloyd, A. Hitchcock, C. MacGregor-Chatwin, A. Iwanicki, I. Ghosh, Q. Shen, C.N. Hunter, and G.S. Engel, "", Journal of the American Chemical Society 145 11659-11668 (2023)

M. Molaei, S.A. Redford, W.H. Chou, D. Scheff, J.J. de Pablo, P.W. Oakes, and M.L. Gardel, "Measuring Response Functions of Active Materials from Data", Proc Natl Acad Sci U S A 120 e2305283120 (2023)

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