Our quantum sensors must accurately attribute detected signatures to corresponding biochemical phenomena to generate high-precision data relevant to cell biology. In this thrust, we will work to develop small, organized two- and three-dimensional arrays of individually addressable quantum sensors that can produce hyper-resolved images of charge, electric fields, or chemical flux across a small (several nm3) volume. For example, we will seek to design a sensor array that can probe local variations in ion concentration immediately proximal to a cell membrane, or clock the flux of second messengers released during signaling. We will calibrate the quantum sensor arrays using well-characterized spatially correlated biological phenomena including the motion of actin filaments, or patch clamp measurements. These nanoscopic sensor arrays will create a new imaging paradigm for investigation of biological fluxes, gradients, and out-of-equilibrium processes at the nanoscale.